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299 Although concerns have been raised about the possibility that SAMe supplementation might increase homocysteine production, a trial in subjects with major depressive disorder found that 8001,600 mg SAMe per day for six weeks did not raise homocysteine levels

Long-term use of some supplements, particularly those with high doses of specific nutrients, may also elevate risks of chronic conditions like diabetes or cardiovascular issues

A variety of factors including the host, microbiological, dietary and environmental factors can disrupt the gut microbiota

Change history 16 April 2024 A Correction to this paper has been published: References Wu, Z