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Additionally, hepatotoxicity is a notable concern, particularly in patients with risk factors such as alcohol consumption, obesity, and diabetes, which can exacerbate liver damage

This capacity allows them to colonize adhesion sites, including colonic crypts, goblet cells, and intestinal villi, in substantial numbers, thereby physically preventing pathogens from gaining a foothold and establishing infection (163, 192)

Consistent with P300, in vitro lactylation assays further substantiated the delactylase activity of SIRT1 (Supplementary Fig

A key feature is its flexible loop 2, which may serve a gating function for substrate binding specificity