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Therefore, hijacking hACE2 may shift RAAS homeostasis and compromise CV function 301

To overcome these limitations of NAC, an amide derivative N-Acetylcysteine amide (NACA) has been created to advance the lipophilicity, membrane permeability, and antioxidant property to increase stability and blood brain barrier penetration

Garthwaite et al., 1992)

Independent groups have observed consistent patterns across the published research record, providing cross-laboratory replication for the core mechanism findings documented in the foundational papers cited above