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in vitro the antimicrobial effect of chitosan on five biofilm-forming periodontal pathogens ( Porphyromonas gingivalis, Prevotella intermedia, Prevotella buccae, Tanerella forsythensis and Aggregatibacter actinomycetemcomitans ) and found that chitosan showed a strong effect against periodontal path-ogens through interference in bacterial co-aggregation, by inhibiting Clostridium vilaceum violacein, thus inhibiting biofilm formation

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