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treatment of the adipocytes with the NNMT inhibitor 5-amino-1MQ resulted in a concentration-dependent increase in the NAD + levels with concentrations in the range of 160 M resulting in ~1.21.6-fold increase in NAD + levels relative to control adipocytes

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this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102

Athletes and individuals who exercise daily may have low B12 levels, due to the increased metabolism