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As porcelain is non-porous, it never experienced much popularity outside of central Europe where meerschaum and briar tended to be much preferred

In support of this approach, prospective studies of smokers in the Shanghai and Singapore cohorts have found that the major nicotine metabolite, cotinine, and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), an established biomarker of the tobacco specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are significantly associated with lung cancer risk after adjustment for self-reported smoking history