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IGF1 inhibits starvation-induced cardiac autophagy via mTOR signaling in vitro , and negatively regulates cardiac autophagy and AMPK activity in vivo (Troncoso et al., 2012)

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

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Given that the cellular thiol network, including GSH, involves crosstalk between the cytosol and organelles, we selected two of the dysregulated enzymes, which had been identified by 2D electrophoresis, with important roles in mitochondrial function, i.e., Aco2 and mitochondrial creatine kinase (mtCK) (Fig