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Chromium (Cr) had the highest mean concentration, while mercury (Hg) had the lowest

The challenges encountered to date with the implementation of this investigator-initiated study have been primarily related to the lack of ready access to matching placebo patches that satisfy the safety and manufacturing requirements of clinical trial regulators in Canada

Establishments are required to post signs stating that sales to minors are prohibited.6,7 Minors are prohibited from buying alternative nicotine products, including e-cigarettes.6,7 No person under 16 years of age may sell an electronic cigarette at a retail establishment (unless child within family-owned business).9 Remote sales of electronic cigarettes require third party age verification

However, electronic cigarettes deliver less nicotine than cigarettes, and other compounds that contribute to addiction in cigarettes are not present in electronic cigarettes, so it is quite possible that e-cigarettes are less addictive than tobacco cigarettes