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First, we note a major challenge is that we do not know how lipid peroxidation ultimately leads to cell death

S., Stout, J., & Wilborn, C

In this sense, it has been reported that binding of mutp53 to particular motifs on non-B DNA conformations, confers stability to mutp53, but also makes it more selective for modifying the activity of both transcription factors and chromatin remodelers (Ghler et al., 2005