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A., Takahashi, K., Palmer, I

Inhibition of ERK can lead to apoptosis, whereas the inhibition of JNK and p38 can prevent apoptosis (Huynh et al., 2003)

Similarly, cullin proteins indirectly interact with one of two RING domain containing proteins (Roc1/Rbx1 or Roc2/Rbx2) which in turn bind to E2 ubiquitin conjugating enzymes