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When measuring this indicator, experimental animals typically need to be euthanized to obtain tissue samples

While recent studies have demonstrated no association between PPI use and all-cause or cause-specific mortality, a growing body of literature supports a correlation between PPI use and increased rates of serious infection including spontaneous bacterial peritonitis (SBP) and liver related mortality in patients with cirrhosis

Flies with Usp8 knockdown exhibited disrupted locomotor activity rhythms and displayed either arrhythmic or lengthened periods, displaying the role of Usp8 in maintaining circadian timing (Luo et al., 2012)

An example of this in relation to glutathione depletion is in acetaminophen (paracetamol) overdose, where the acute poisoning causes a severe and dramatic loss of cellular glutathione, especially in the liver