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Cerebellar Microglia and Neuronal Pathology Cerebellar inflammation, neuronal loss, and associated functional impairments are observed in both patients and animal models of various brain and systemic disorders, including ataxias, neurodegeneration, autism spectrum disorders (ASD), metabolic pathologies, and aging (Smith et al., 2019

The result is the formation of ROS (superoxide, hydrogen peroxide), which stimulates the downstream activation of matrix metalloproteinases -2 and -9

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