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A double-blind, placebo-controlled trial in 95 patients with irritable bowel syndrome or inflammatory bowel disease and normal B12 levels found no significant improvements in fatigue, although B12 levels increased in the B12 group who received 1000 g per day per os (p.o.) for 8 weeks (form not reported)

As a result, we tested several versions of the MLR model, varying the lags of the predictors and substituting the Nio 3.4 SST index for the MEI, and all results were similar for each model