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How This Works 5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small molecule not a peptide that selectively inhibits nicotinamide N-methyltransferase (NNMT) [1]

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Mouse models lacking Parkin or PINK1 develop motor deficits and dopaminergic neuron loss when subjected to mitochondrial stress, particularly in combination with the mutator mouse model, which accumulates mtDNA mutations due to POlG dysfunction [60]

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