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As systemic metabolic function improves, secondary benefits such as enhanced muscle definition, improved skin tone, and overall physical refinement may be observed, reflecting improved cellular energy balance and reduced inflammatory burden

In addition, a Class II randomized clinical study evaluating chorea after tetrabenazine withdrawal reported that the discontinuation of tetrabenazine was significantly related to reemergent chorea [15]

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Before staining, the slices were washed in 0.1 M PBS thrice and incubated for 1 h in blocking solution (4% Donkey Serum, 0.3% Triton X-100 in 0.1 M PBS)