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aptamers have also been used to bind larger targets such as proteins and cells [251264]

Written informed consent was obtained from all participants prior to enrollment

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These inconsistent findings highlight the challenges in translating preliminary signals into robust clinical effects and indicate that, at present, there is insufficient evidence to support the routine use of arbaclofen in ASD (149151).In another randomized, double-blind, placebo-controlled trial in children with FXS, ganaxolonea GABAA receptor positive allosteric modulator with a favorable safety profilefailed to show significant improvement over placebo on the primary outcome (CGI-I) or the key secondary outcome (PARS-R) in the overall population