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Researchers observed that intra-articular administration was associated with changes in cartilage matrix composition and chondrocyte activity markers in the treated joints compared to controls [3]

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Abiotic stressors such as cold, drought, heat, salinity, and flooding negatively impact plant growth and productivity, causing various physiological, morphological, molecular, and biochemical changes ( Figure 1 ) (Popp et al., 2013)

MTX is mostly taken up by cells via the SLC superfamily of transporters such as SLC19A1, SLC21, SLC22, and SLC46A and can be pumped out by different ABC (Desmoulin et al