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Clin Cancer Res 5(7):1758-66, 1999

doi: 10.1159/000538490 188 SunXFengXZhengDLiALiCLiSet al

This mechanism may also represent a crucial molecular basis for fibroid heterogeneity and recurrence

Tocilizumab (Actemra ) is a humanized monoclonal antibody with activity against both the membrane and soluble forms of IL-6R approved to treat moderate to severe rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, and Castlemans disease (151)