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Although our in vivo data robustly demonstrate multi-system recovery, the intricate cellular and molecular crosstalk underlying these effects invites further elucidation through reductionist in vitro models

Under physiological conditions, a healthy gut microbiota and an intact intestinal barrier are critical for establishing immune tolerance ( The tumor immune microenvironment (TIME), a dynamic ecosystem of cancer cells, stromal cells, ECM, and diverse immune cells, profoundly shapes tumor progression and therapeutic responses ( A pivotal mechanism linking gut dysbiosis to pro-tumorigenic inflammation is the translocation of microbial components, most notably lipopolysaccharide (LPS), across a compromised intestinal barrier ( Beyond TLR-dependent microbial sensing, the NF-B pathway serves as a critical signaling hub that integrates diverse pro-tumorigenic stimuli within the TIME

Formulated as a plant-based, vegetarian option, these capsules harness a naturally occurring intracellular thiol and low molecular weight tripeptide found in living cells

doi: 10.1038/s41419-024-06745-z 96 ZhouJ.FengD.LiX.ChenY.ZhangM.WuW.et al