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Emerging evidence suggests that autophagy may significantly contribute to the pathogenesis of PCOS ( Beyond follicular dynamics, autophagy is essential for maintaining normal oocyte and granulosa cell function, as well as modulating insulin signaling ( e.g ., IL-1, IL-18), thereby mitigating chronic inflammation

In a preliminary approach using data from a panel of patient-derived xenografts in mice [10], an efficacious concentration range of 120 to 700 ng/mL (0.3 to 1.8 M) M8891 in mouse was estimated, showing a clear doseresponse relationship (data not shown)