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Importantly, matrix stiffness can activate the epithelial to mesenchymal transition (EMT) program, resulting in a partial EMT state [79], which is distinguished by the simultaneous presence of both epithelial and mesenchymal traits, enabling a more efficient collective cell migration and invasion [80]

When an oxidative stressor or electrophile interacts with the Keap1-Nrf2 complex, it allows for the release and subsequent nuclear accumulation of Nrf2 through a complex process of ubiquitination-inhibition, thus triggering an anti-stress response by the cell

Lalezar, in her treatment of Parkinsons patients using intravenous glutathione, has reported significant success in improving their condition

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