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The endodermal lineage is the germ layer which contributes to a number of critical organs including the thymus, lungs, liver, pancreas, and intestines 1

PMID: 40200123 Acta Pharmacol Sin KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis

The flip side is also true: mast cell inhibitors dramatically reduced lung lesions and mortality from the flu.[ref] Other substances that activate mast cells: IgE activation is just one way a mast cell activates during its normal pathogen-fighting function

It is also directly impacted by insufficient choline intake (a type of B vitamin) and imbalanced gut bacteria