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Paradoxically, in advanced KOA with osteoporosis comorbidity, Bacteroidetes abundance positively correlates with disease progression and enriched in murine intestinal inflammation models (Longo et al., 2024)

Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection (Cardona-Gmez et al., 2006)

Interestingly, RSL3-induced ferroptosis could be inhibited by higher expression levels of mitochondrial ferritin under hypoxic conditions [60]

However, due to the pleiotropic roles of STAT proteins in immune and non-immune cells, selective targeting of STAT pathways in MDSCs remains a challenge