how long have people been smoking tobacco History of Reflections | Smoking in China:

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The results also suggested that smoking was associated with worse overall health, with smokers reporting more frequent and more severe neurological worsening

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The study, led by researchers at the Medical University of South Carolina, found that people who smoked unfiltered cigarettes were 40 percent more likely to develop lung cancer and nearly twice as likely to die from it than those who smoked filtered cigarettes