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Inhibition of mTOR by rapamycin has been shown to reduce SASP-related factor production

The third mechanism involves decreased drug uptake due to changes in membrane permeability, caused by alterations in the characteristics of the porin channel

doi: 10.1016/j.biotechadv.2013.06.007, 78 NapoleoniM.KlennerF.KhawajaN.HillierJ

844 Ferroptosis in intestinal ischemia/reperfusion injury Intestinal ischemia/reperfusion (I/R) injury occurs in many clinical conditions, such as acute mesenteric ischemia, small intestine torsion, and trauma, and is a life-threatening vascular emergency