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Experimental evidence revealed a significant increase in KEAP1-RBM45 binding in cytosolic fractions from ALS lumbar postmortem spinal cord compared to controls

Quercetin can effectively block the release of human mast cell cytokines, helping to calm the systemic inflammatory storms that drive MCAS flares

10.1007/s00380-005-0873-1 114 ODonoghueM

As a matter of fact, taking into full account the intricacy of the numerous regulatory mechanisms involved in OS control as well as the complex interplay between the many events that contribute to the progressive degeneration and death of MNs, future neuroprotective pharmacological therapies will likely need to aim for an integrated treatment, acting on several levels to limit the progression of the disease