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Jelinek, Khalifa University, United Arab Emirates Reviewed by Qinghe Meng, Upstate Medical University, United States Navid Abedpoor, Islamic Azad University, Iran Updates Copyright 2026 Ranasinghe, Mathai and Zulli

Lower, physiological doses often produce significant effects on sleep and hormonal regulation, while higher, supraphysiological doses may show diminished or even paradoxical effects

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For example, NAMPT expression changes during diseases such as cancer, diabetes, and fatty liver disease 211 , and eNAMPT levels decrease with age 328