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Regul Toxicol Pharmacol 29, S110

doi: 10.1016/j.apsb.2015.06.002, 103

Schulz et al., 2007

Deficiency of substrate L-Arg and accumulation of ADMA L-Arg is the substrate for eNOS and the main precursor of NO, therefore, the availability of L-Arg is important for the activity of this enzyme, and the substrate insufficiency may lead to eNOS uncoupling (Fig