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Disagreements were solved by the consensus of a third author (F.F.) The studies had to include individuals with a clinical diagnosis of any type of dementia and severity according to the internationally accepted guidelines or diagnostic criteria

Third, research remains unbalanced, focusing mainly on macrophages while underexploring ferroptosis interplay with neutrophils, dendritic cells, and lymphocytes, thus hindering a full view of the periodontal immunopathological network (64, 112, 113)

FIGURE 4 On the other hand, the activity of glutamate dehydrogenase (GDH), a mitochondrial Krebs cycle-associated enzyme, was decreased significantly in the GK rat liver (40%), which recovered after the exercise regimen (Figure 4B)