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In the integrated transcriptomics and metabolomics investigations, the ferroptosis pathway ranked first among the co-enriched pathways, and the level of GSH was significantly increased after RY-A treatment

By activating the VDR signaling pathway, these probiotics ultimately promote vitamin D absorption and the expression of its target genes, such as the antimicrobial peptide cathelicidin, thereby exerting anti-inflammatory effects (Wu et al., 2015)

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The resolution of this debate likely hinges on technical advancements that allow direct, compartment-specific measurement of metabolic fluxes and oxygen dynamics in the tissue parenchyma