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Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis

a NNMT inhibitor such as a cation of Formula I or IA, or otherwise disclosed herein one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

[DOI] [PubMed] [Google Scholar] [96].Leeder JDC, Godfrey M, Gibbon D, et al

This is achieved through oxidative damage to pathogen membranes