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In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells

To further verify if the effects of H 2 O 2 treatment on mitochondrial proteostasis and mitophagy were indeed mediated through cysteine deprivation and CLPXP complex inactivation, the three cancer cell lines were treated simultaneously with both H 2 O 2 and cysteine (H 2 O 2 +Cys) or H 2 O 2 , ZK53 and CLPP overexpression (H 2 O 2 + ZK53 + CLPP OE)

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