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Preclinical studies have shown that PD-1/PD-L1 blockade can mobilize monocyte-derived macrophages, enabling their infiltration into the brain to reduce pathology and combat cognitive decline in 5XFAD AD mice [350, 351]

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Additional risks specific to the bodybuilding context include: Cardiovascular strain: Increases in resting heart rate have been observed with GLP-1 receptor agonists as a class (as documented in the Summary of Product Characteristics for licensed agents such as semaglutide and tirzepatide)