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In the early 21st century, when no disease-modifying treatments for AD were available, diagnostic biomarkers with mechanistic specificity, such as CSF A 142 /tau ratios or amyloid PET imaging, began to serve a dual role as selection biomarkers in clinical trials

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Ther Adv Drug Saf 4(1):57 Duan LP, Wang HH, Ohashi A, Wang DQ (2006) Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects