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These changes can lower the threshold for pathogenic syn misfolding and aggregation, thereby exacerbating neurodegeneration [33]

Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord

All animals were housed in a clean, temperature-controlled environment with ad libitum access to food and water, and bedding was changed regularly to maintain hygiene

it performs various functions, controlling sleep patterns, adjusting the circadian rhythm, contributing to the immune response, protecting oocytes from ROS, and is also considered a free radical eliminator and an endogenous antioxidant