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The DOR profile may be similar to that of aged ovaries, since the same study also discovered increased levels of miR-128-3p, which resulted in decreased expression of TGFBR1 and a change previously observed in older women

We would then use these adjusted expenditure calculations as new inputs along with other original calculations that were not adjusted for the impact of improper payments (such as the ACO's historical benchmark for PY 2022) to recalculate the ACO's financial performance for PY 2022, following the standard financial methodology described in 425.605 (for ACOs participating in the BASIC track) or 425.610 (for ACOs participating in the ENHANCED track), as applicable