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It is evident that different in vivo models develop a broad spectrum of symptoms and severity according to the species, but also to the technique adopted for their generation

We strongly encourage discussing any concerns with our medical team and consulting with your primary healthcare provider before starting any new treatment

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Additionally, while ceramides promote apoptosis by BAX dependent mechanisms, sphingolipid metabolism co-operates with BAK/BAX dependent mechanisms to promote permeabilization of the mitochondrial outer membrane (MOMP) (135, 136)