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Am J Physiol Heart Circ Physiol 2019;316(1):H61-9

Though overall the risk remains low, oral estradiol is associated with increased venous thromboembolism (VTE) risk, whereas transdermal estradiol was not found to be associated with significant increased risk of VTE.7 The reason for the discrepancy is thought to be the result of procoagulant factors being formed as a result of first pass hepatic metabolism for estradiol, a factor that doesnt apply to the transdermal route

Figure 1 Figure 2 2.3 Author analysis Price argues that half of all publications on the same theme are authored by high-productivity authors, with the number of these authors being equal to the square root of all scientific authors ( n max indicates the number of publications the author of the most published articles

[PMC free article] [PubMed] [Google Scholar] Niwano T., Terazawa S., Sato Y., Kato T., Nakajima H., Imokawa G