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Challenges Due to the lack of specific DHFR activators, there are no clinical studies that examined the possibility of stimulating its activity to increase NO availability

Experimental models frequently employ the natural neurotoxin kainic acid to trigger excitotoxic neuronal death, providing a well-established paradigm for studying neurodegeneration [98]

Root morphological parameters, including surface area and total length, were measured using root analysis software (WinRHIZO 2008a)

[6] Since many antioxidant treatments stimulate apoptotic pathways, [7,8] the potential exists for a synergistic effect with radiation or chemotherapy with antioxidants