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Quoting from the Dar 2005 study, "The present secondary analysis of the data elucidates these placebo effects by showing that reduction of smoking was strongly related to participants beliefs about their drug assignment

Lo Tam Loi AT, Hoonhorst SJM, Franciosi L, Bischoff R, Hoffmann RF, Heijink I, et al: Acute and chronic inflammatory responses induced by smoking in individuals susceptible and non-susceptible to development of COPD: from specific disease phenotyping towards novel therapy

Let the device sit for a few minutes to allow the e-liquid to saturate the coil properly, which helps avoid dry hits

Throughout the study, subjects used cannabis as they typically would