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This delayed activation of the transcription factor is caused by the temporal inactivation of Tpx1 by high doses of peroxides, which accumulates with its peroxidatic Cys in the sulfinic acid form

Role of Surgery in Metastatic Disease/Current Controversies

Since the energy requirements for glutamate uptake are extremely high, the reversal of glutamate transport is preceded by a decline in astrocytic glutamate uptake, which signifies the earliest astrocytic contribution to the development of glutamate excitotoxicity, together with the already reversed glutamate uptake in neurons (Rossi et al., 2000)

Dig Dis Sci 57: 29102916 Burchard J, Zhang C, Liu AM, Poon RTP, Lee NPY, Wong KF, Sham PC, Lam BY, Ferguson MD, Tokiwa G et al (2010) microRNA122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma