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A broader range of doses and the administration frequency should be assessed in both the preclinical and clinical studies of 7nAChR ligands

Peroxisomes and mitochondria also engage in intimate crosstalk to coordinate lipid oxidation and ROS detoxification

Such compounds are able to inhibit SystemX c , thus leading to exhaustion of cysteine in cells, GPX4 inactivation, accumulated lipid peroxides, and eventually ferroptotic cell death

150,151,152,153 In animal models with reduced F/B ratios, the expression of mucin and ZO-1 in the intestinal barrier, as well as the expression of anti-inflammatory factors, is increased, whereas the expression of the proinflammatory cytokines TNF-, IL-1, and IL-6 is inhibited, and disease symptoms are largely reversed