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In vivo, treated mice showed significantly reduced body weights, white adipose masses, and adipocyte sizes findings replicated across multiple independent studies from the same research group

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Several clinical trials in mice, rodent models, non-human primates and humans were performed, concluding that the GLP1/GIP multi-agonist therapy reduced food intake, and consequently body weight, improved glycemic control, lipid profile and lipolysis but without any improvement in energy expenditure

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