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Many studies from animal models to human clinical data reported that plasma Cu levels are significantly elevated along with hypercholesterolemia in atherosclerotic subjects [140, 141]

10.1007/s13311-020-00968-6 139 SantocchiE.GuiducciL

The 90-degree angle (straight in) is appropriate when adequate tissue depth is present and no pinch is needed

Moreover, although the autophagy of mitochondria (mitophagy) may sequester iron in mitophagosomes to prevent iron from releasing into the cytoplasm in the early stages of iron overload, extensive mitophagy can conversely trigger Fe 2+ liberation, elevate cytosolic Fe 2+ levels, and amplify ferroptosis (Yu et al., 2022