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Supplementation with indole-3-propionic acid (IPA), a metabolite produced by GM from tryptophan, reduces the F/B ratio, and also reduces diastolic dysfunction and HFpEF-induced diastolic dysfunction and HFpEF-induced cardiac hypertrophy in the heart by inhibiting the expression of pro-inflammatory cytokines, such as TNF-, IL-6, and IL-1 in the heart of mice [110]

Bocian-Ostrzycka KM, Grzeszczuk MJ, Bana AM, Jagusztyn-Krynicka EK (2017) Bacterial thiol oxidoreductasesfrom basic research to new antibacterial strategies