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To investigate whether autophagic activity was affected by MCUR1 loss-of-function, we measured LC3B-II accumulation under stress by immunoblotting

Pharmacological approaches have limitations due to side effects and added burden to patients with cachexia, who are taking multiple medications and experiencing treatment-associated side effects

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Eligible studies included those involving adult patients diagnosed with a mood disorder ie., MDD or BD and receiving pharmacological treatment with ALC, either as monotherapy or as an adjunctive treatment