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Description

Only a small number of preclinical animal studies have been performed so far ( Table 1 )

GHRP-6s NPY/AgRP activation introduces a variable that can independently modulate GH pulse frequency in certain model contexts a subtle but real confound in studies where pulse frequency, not just amplitude, is a primary endpoint

Researchers studying pulsatile GH kinetics may select the shorter-acting compounds to model physiological pulse patterns, while those studying downstream IGF-1 effects may favour ipamorelin's extended peak to ensure adequate GH receptor engagement duration