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Glycine may also become limiting in some people, particularly with aging or inadequate protein intake

In response to questions, McNeil first wrote in an email that 8 grams, or double the maximum daily dose, over several days can damage the liver

A smaller subset of cases (approximately 4%) involves one allele with a GAA repeat expansion and the other allele carrying a different mutation, such as a deletion or point mutation (Bidichandani, 1998)

These findings emphasize the metabolic heterogeneity of GBM and highlight glycolysis not just as an energy strategy, but as a fundamental driver of tumor proliferation and biosynthesis