glutathione synthetase deficiency schizophrenia and glutamate in schizophrenia: a 7T MRS study PDF) Schizophrenia and Glutathione: A

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Of the glutathionylation-related enzymes, the glutathione S-transferases (GSTs) superfamily was classically identified as phase II detoxifying enzymes that contribute to neutralizing exogenous as well as endogenous electrophiles, including ROS, through the conjugation of glutathione (GSH) 9,10,11

During the ischemic phase, the rapid depletion of ATP leads to a significant decrease in mitochondrial membrane potential, which in turn triggers electron transport chain dysfunction