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doi: 10.1016/j.biopha.2023.115547 248 SohnsCZabelM

A phase I clinical trial assessed the safety and immunogenicity of a tailored mRNA vaccine (mRNA-4650) that encodes specific neoantigens, mutations in driver genes, and HLA-Ipredicted epitopes in four extensively pretreated patients with metastatic gastrointestinal Malignancies

[101] Toxicity due to size of nanoparticles [edit] Toxicity in certain systems can also be dependent on the size of the nanoparticle

Stimulation of glutaminergic receptors also leads to the activation of focal adhesion kinase, which regulates the proliferation and motility of malignant glioma cells